Login to view secured documents.

Distributor Login

ARS ON-LINE SAMPLING SYSTEMS

*IFPAC Annual Meeting - DASGIP and Groton Biosystems make presentation on automated feeding control. Acrobat PDF
The FDA Process Analytical Technology (PAT) Initiative provides a risk based framework - supported by regulatory authorities - to employ new automation methods in order to improve the efficiency, quality, and yield of biological manufacturing. Reactor feeding is a necessary operation that is still performed manually in most facilities that is easily automated. Reactor samples are currently taken manually by operators then analytical results are obtained from offline nutrient analyzers and the adjustment of feeding additions are based on these results and other factors calculated off line. The correction is done manually. However, fully automatic feeding control of bioreactors is possible today and is a key link in the quest to improve biologics manufacturing. This discussion will explore the mechanisms and requirements to perform automatic feeding of reactors through automatic, sterile, online sampling integrated with nutrient monitoring, process modeling, and reactor control proving a closed loop feedback control for nutrient feedstocks. Automated feeding control of substrates and amino acids has been performed in operating bioreactor facilities and the results will be discussed.

*New Horizons in Bioreactors adn Bioprocessing: Automated Bioreactor Feeding Acrobat PDF
Presentation given by Groton Biosystems, DASGIP and YSI Life Sciences at the Live Demonstration in Ft. Washington, PA (April 20, 2010) and Rockville, MD (April 22, 2010).

Automated Reactor Sampling and Agilent 1200 Series LC System for Online HPLC Assays Acrobat PDF
Increase efficiency with a powerful process analytical technology solution for the biopharmaceutical Industry.

Genentech - Implementing an Automated Reactor Sampling System for Monitoring Cell Culture Bioreactors Acrobat PDF
Process Development Engineering. Monitoring of cell culture bioreactors is critical to process control and optimization. Currently offline sampling is used in various cell culture operations. This process is time consuming and labor intensive. Automating the sampling process is highly desired but concerns about sterility, sample volume and cross contamination are common. This paper presents the evaluation of an automated sampling system by Groton Biosystems.

Simulating a Bacterial Contamination in a Novel Automated Bioprocess Acrobat PDF
Department of Chemical Engineering at Massachusetts Institute of Technology (MIT), Cambridge, MA

U of Maine - On-line Solutions for Bioethanol Fermentation Analyses Acrobat PDF
Yeast fermentation converts sugar to alcohol under anaerobic conditions. In this study and ARS400 was operated to take samples from a BioFlo110 three liter fermentor drawing samples containint E. coli K011 bacteria cells.

Capillary Electrophoresis PAT Applications Acrobat PDF
Application of capillary electrophoresis systems for at-line and near-line biological API production analysis.